Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary – National Research Council [US] – 2014
Authors: Douglas Friedman and Joe Alper, Rapporteurs; Chemical Sciences Roundtable; Board on Chemical Sciences and Technology; Division on Earth and Life Studies; National Research Council
Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery.
Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome.”Read Full Post | Make a Comment ( Comments Off on Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary – National Research Council [US] – 2014 )
Progress in the implementation of the recommendations of the 1999 Joint Expert Technical Advisory Committee on Antibiotic Resistance – Senate Finance and Public Administration Committee – June 2013
“Terms of Reference
1.1 On 29 November 2012, the Senate referred the following matters to the Finance and Public Administration References Committee (the committee) for report by 21 March 2013:
Progress in the implementation of the recommendations of the 1999 Joint Expert Technical Advisory Committee on Antibiotic Resistance (JETACAR), including:
(a) examination of steps taken, their timeliness and effectiveness;
(b) where and why failures have occurred;
(c) implications of antimicrobial resistance on public health and the environment;
(d) implications for ensuring transparency, accountability and effectiveness in future management of antimicrobial resistance; and
(e) any other related matter.1
1.2 The reporting date was subsequently extended to 7 June 2013.”Read Full Post | Make a Comment ( Comments Off on Progress in the implementation of the recommendations of the 1999 Joint Expert Technical Advisory Committee on Antibiotic Resistance – Senate Finance and Public Administration Committee – June 2013 )
Infections and the rise of antimicrobial resistance – Annual Report of the Chief Medical Officer [NHS] – 11 March 2013
Chief Medical Officer publishes volume 2 of her annual report – 11 March, 2013
“The second volume of Professor Dame Sally Davies the Chief Medical Officer’s annual report provides a comprehensive overview of the threat of antimicrobial resistance and infectious diseases.
The report highlights that, while a new infectious disease has been discovered nearly every year over the past 30 years, there have been very few new antibiotics developed leaving our armoury nearly empty as diseases evolve and become resistant to existing drugs.
In addition to encouraging development of new drugs, the report highlights that looking after the current supply of antibiotics is equally important. This means using better hygiene measures to prevent infections, prescribing fewer antibiotics and making sure they are only prescribed when needed.”Read Full Post | Make a Comment ( Comments Off on Infections and the rise of antimicrobial resistance – Annual Report of the Chief Medical Officer [NHS] – 11 March 2013 )
New CDC Vital Signs: Lethal, Drug-resistant Bacteria Spreading in U.S. Healthcare Facilities – 5 March 2013
“Drug-resistant germs called carbapenem-resistant Enterobacteriaceae, or CRE, are on the rise and have become more resistant to last-resort antibiotics during the past decade, according to a new CDC Vital Signs report. These bacteria are causing more hospitalized patients to get infections that, in some cases, are impossible to treat.”
… continues on the site
“Untreatable and hard-to-treat infections from CRE germs are on the rise among patients in medical facilities. CRE germs have become resistant to all or nearly all the antibiotics we have today. Types of CRE include KPC and NDM. By following CDC guidelines, we can halt CRE infections before they become widespread in hospitals and other medical facilities and potentially spread to otherwise healthy people outside of medical facilities.”
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Culture of Resistance: Australia’s response to the inappropriate use of antimicrobials – The Australia Institute – 15 February 2013
“This paper looks at how Australian governments have responded to anti-microbial resistance (AMR) since the problem became evident in the 1980s.
Of particular importance in Australia’s response was the 1999 establishment of the Joint Expert Technical Advisory Committee on Antibiotic Resistance (JETACAR), which was set up to provide independent expert scientific advice on the threat posed by antibiotic-resistant bacteria to human health by the selective effect of agricultural use and medical overuse of antibiotics.
JETACAR report provided a ‘five point plan’ covering regulation, monitoring and surveillance, infection prevention, education and research – the basics of which were equally applicable to human and veterinary medicine.
The government generally accepted the recommendations of the report, stating that there was international concern about AMR and that Australia needed to respond with strategies that were “consistent with and complementary to global initiatives”.
Initially there appeared to be strong commitment to implementing the recommendations of the 1999 JETACAR report, but many initiatives failed to result in any comprehensive systematic response to the issue. Committees, taskforces and groups were set up but disbanded, strategies were developed but not implemented, pilot programs failed to be anything other than pilot programs; undertakings were not carried out.”
ISSN 1836-9014Read Full Post | Make a Comment ( Comments Off on Culture of Resistance: Australia’s response to the inappropriate use of antimicrobials – The Australia Institute – 15 February 2013 )
“ResistanceMap is a web-based collection of tools that allow accessible, engaging, and interactive exploration of more than 50 antimicrobial surveillance indicators from North America and Europe.
Researchers, policymakers, and the public can use the Map to gain insight into the trends and magnitude of an unfolding public health crisis. To reach a wider audeince, visualizations may be reembedded on any blog or website.”Read Full Post | Make a Comment ( None so far )
“How reimagining data – and reframing a problem – can help avert a looming public health crisis
For the first time, researchers and policymakers can visually track the rise in “superbug” infections over time and identify regions of the country with rapidly spreading rates of resistance.
Researchers at Extending the Cure, a nonprofit project funded by the Robert Wood Johnson Foundation’s Pioneer Portfolio, have developed ResistanceMap—an online tool that tracks changes in resistance levels. These maps show us how the problem of antibiotic resistance has gotten worse–with some regions of the country experiencing a significant and worrying increase in drug- resistant microbes.” … continuesRead Full Post | Make a Comment ( None so far )